Before diving into the more detailed solutions to fix your mouse settings on Windows 10, check if booting your PC with bare minimums sorts out the mouse issue. Also, make sure if your mouse is working fine on another system (or another mouse works fine on your system). Also, check if reinstalling the mouse driver in the compatibility mode solves the problem.
Update The PC’s Windows to the Latest Build
The mouse settings may keep resetting if the Windows of your PC is outdated as it may cause incompatibility with other drivers/OS modules. Updating the Windows of your PC (along with the system drivers) may solve the problem.
Run the Hardware Troubleshooter
The mouse resetting issue could be a result of a temporary malfunction of the hardware modules of the system and running the Windows built-in hardware troubleshooter (one of many troubleshooters) may solve the problem.
Use the Mouse Controlling Software
If you are using a mouse controlling application like Logitech Setpoint whose settings are overwriting the OS mouse settings, then the mouse setting may keep resetting in the OS. In this context, using the mouse controlling software to set the required settings or setting the controlling application to not overwrite the OS implementations may solve the problem. For illustration, we will discuss making the changes in the Logitech Setpoint application. If that did not do the trick or you are not able to locate your mouse controlling applications, then follow the under-mentioned steps to sort out the issue:
Clean Boot Your PC and Uninstall the Conflicting Applications
The mouse settings of your Windows system may keep resetting if an application on the system is interfering with the mouse settings of your system. In this context, clean booting your Windows PC (to filter out issues from a startup item) and uninstalling the conflicting applications may solve the problem. Following are the applications reported by users to cause the mouse resetting issue: So, if you have any of these applications or a similar one, then uninstalling that application may solve the problem. For illustration, we will discuss the process of uninstalling the Logitech Setpoint.
Create a New Profile/Scheme of the Mouse Settings
If none of the solutions did the trick for you, then you may have to create a new profile/scheme of the mouse settings in the mouse controlling application, and switching to that profile after every system restart (till the issue is permanently solved). If the issue persists, then check if editing the XML file of the driver (a task for tech-savvy users) resolves the issue. If that is not an option or not possible, then you may have to perform a clean installation of Windows.
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